So, what is CurQfen; CurQfen is bioavailable curcumin powder truly extracted from turmeric with FenuMAT™ technology. This Curcumin powder lies in its ability to provide the bioactive free-form of curcuminoids to plasma and further into tissues, with improved blood-brain-barrier permeability and therefore CurQfen setting up new benchmark in bioavailability of curcumin, more than just the…
Recent understanding of the relative bioactivity and membrane permeability of free curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) over conjugated metabolites like curcumin glucuronides have demonstrated higher bioactivity and permeability for free curcuminoids. Cell-based studies have reported no anti-inflammatory effect and anti-cancer effect to curcumin glucuronides. The situation has created a great interest to develop new bioavailable formulations capable of providing significant levels of bioactive free (unconjugated) curcuminoids in the blood for a longer duration to translate the therapeutic efficacy of curcumin to human beings. Thus, there is a paradigm shift in the new measures of the efficacy parameters of a bioavailable curcumin as absorption, elimination half-life (pharmacokinetics), and cell uptake (membrane permeability), despite the mere numbers of folds of bioavailability claims. Cellular uptake of the bioactive forms is an important factor for curcumin to exhibit its pleiotropic properties; that is, for the multi-targeted action by interaction with the genome (DNA), messengers (RNA) and enzymes (proteins) within the cells.
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