CurQfen® – FAQ

CurQfen® contains not less than 35% of curcuminoids, as the sum of curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), which means that each lot will have not less than 28% curcumin, 6.13% DMC and 0.88 % BDMC. 500 mg of a single 0 size capsule will have approximately 140mg Curcumin, 30.65mg DMC and 4.4mg BDMC with a total curcuminoids content of 175 mg.

CurQfen® is the one and only formulation which is 100% natural. It is free from any synthetic emulsifiers such as polysorbate (Tween 80), glycerine, silica, microcrystalline cellulose, maltodextrin, polyvinyl alcohol, magnesium sterate, saturated fatty acids like palmitic acid etc..

CurQfen® is manufactured by a water-process employing standard unformulated curcumin and fenugreek dietary fibre. The fibre is produced by a proprietary process without using any solvents. So, the only solvents in CurQfen® are the ones used for its isolation from turmeric rhizomes. Either acetone, ethanol or ethyl acetate can be used as desired by the customer. No hexane or chlorinated solvents would be involved in the
process.

CurQfen® is manufactured in a GMP certified plant with ISO 9001, ISO 14001, BS OHSAS 18001 & FSSC 22000. It is 100% vegan, non-GMO, gluten-free, halal & kosher certified. And it also hold self-affirmed GRAS and USA patent. CurQfen® is a CLEAN-LABEL ingredient.

CurQfen® is food-grade and suitable for powder beverages (sachets, stick packs, Golden milk), protein bars, protein supplements, gummies, yogurt, instant soup powders, chocolates, etc at 100 to 200 mg/serving size without taste issues. CurQfen® is the only bioavailable formulation of CurQfen® that has been used as a functional food ingredient and the bioavailability from the food matrix has been confirmed on humans at 100 mg dosage/serving size (Food & Function, 2014). It is water dispersible and can dissolve completely on stirring. However, a significant settling may observe on standing the water solution. But, it is good for liquid shots and liposomes.

CurQfen® does not contain any phytochemicals in fenugreek since purified dietary fibre is used for the formulation. It is de-bitterised making it suitable for food applications.

CurQfen® is just a formulation using Fenugreek dietary fiber; – a prebiotic fiber that has been clinically substantiated for a number of health beneficial pharmacological effects, including blood-sugar and cholesterol management effects (Hypoglycemic & Hypolipidemic) and Gastroprotective effects. It has been found to slow down gastric emptying and improves satiety and reduces heart burn. It can hold nearly 25 mL of water/gram and hence increases the bulkiness and helps to manage constipation. It is non-digestible, ferments in the colon to produce short chain fatty acids and is a good colon cleanser. However, 1 to 2% of population have been shown to have diarrhoea-like symptoms even with unformulated curcumin.

The current practice of expressing curcumin bioavailability in the market place is ‘the measurement of plasma concentration of curcumin glucuronides/sufates’ by hydrolysis with β-glucuronidase enzyme and expressing it as ‘curcumin’ bioavailability as the NUMBER OF FOLDS of enhancement. So, the declared bioavailability is that of curcumin-glucuronides/sulfates only; NOT the ‘curcumin’ bioavailability. In the light of the recent studies that curcuminglucuronides have no anti-inflammatory & antiproliferative and anti-amyloidic activities, there exist a great need for a new generation of bioavailable curcumins’ capable of
delivering FREE curcuminoids.

CurQfen® is a new generation bioavailable curcumin in this respect. It is the only bioavailable curcumin in the market place whose FREE curcuminoids bioavailability has been confirmed and quantified by Triple quadruple, time-of-flight (TOF), and ion Trap tandem mass spectrometric analysis. CurQfen® is the only formulation which has been shown the relative distribution of free curcuminoids in plasma over the conjugated curcuminoids. That is, how much curcuminoids in plasma is in free form and how much as glucuronides. So, CurQfen® is talking about the latest understanding on curcumin absorption, beyond the “number of folds”.

Moreover, BBB-permeability, brain-regional distribution pharmacokinetics, organ tissue distribution (cellular uptake), and clinical studies on brain, heart, liver and joint-health at relatively low dosage of 500 mg/day. It is also 100% Natural & CLEAN LABEL with no synthetic excipients, which makes CurQfen® unique and novel.

The current understanding on curcumin pharmacokinetics and pharmacodynamics urge for non-NANO & natural delivery forms (regulatory compliance) capable of providing FREE curcuminoids over conjugated metabolites and proof for the same. It has to be noted that even unformulated curcumin has been shown to provide free curcuminoids into plasma and absorbs via lymphatic system, though majority of absorption is via blood. In 2008, Begum et al detected and estimated curcuminoids in rat plasma and brain tissues at significantly high levels when chronically fed with 2000 ppm curcumin, indicating that ‘unformulated curcumin’ can provide free curcuminoids in plasma, further to brain tissues and can lead to amyloid-plaque reduction ( J Pharmacol Exptl Ther, 2008, 321, 196-208) . But, once it is metabolised to conjugates (glucuronides/sulfates), all these properties are getting lost. So, a new generation bioavailable curcumin should talk about the ratio of plasma concentration of free curcuminoids to conjugated curcuminoids (FCR), more than the number of folds of bioavailability. FCR will reflect how much curcuminoids are absorbed in free form and how much in conjugated form. Higher the FCR, better the formulation (JFF 2016).

CurQfen® is the only formulation which has determined FCR of 1.3. Once free curcuminoids are available in the systemic circulation, it gets automatically absorbed into brain and other tissues. So, brain tissue distribution is a litmus test for free curcuminoids bioavailability. CurQfen® has addressed and proved all these check points and published in peer reviewed journals (JFF 2015, 2016). It is 100% Natural, food-grade, CLEAN label and free from excipients.

As per the clinical study on 50 subjects, CurQfen® has 45-fold free curcuminoids bioavailability as compared to the total absorption of 1000 mg single dose of unformulated curcuminoids 95%, when performed a triple quadruple-electrospray ionisation tandem mass spectrometric study (Kumar et al., 2016). When compare the bioavailability of total curcuminoids as the sum of free and conjugated curcuminoids with respect to the respective curcuminoids upon a single dose of 1000 mg unformulated curcuminoids 95%, it is 270-fold bioavailable.

Three levels of mass spectrometric evaluations using Triple quadruple, Time of flight and Ion trap tandem mass spectrometry were used to confirm the curcuminoids and their metabolites.

The identification of unique physicochemical properties of fenugreek galactomannans and the invention of a proprietary water-based mechanical process for the isolation of a unique composition of phytochemicals free and debitterised dietary fibre were the key. It binds with curcuminoids in high affinity and forms amorphous curcumagalactomannosides (curcumin-galactomannan biocomplex or CGM) exhibiting mucoadhesive character. CGM swells extensively in the gastrointestinal tract, binds with the epithelial membranes and leaches the colloidal nano sized soluble curcuminoids (sustained release) from the galactomannan network and absorbs via both circulatory and lymphatic systems.

CurQfen® has been studied for its pharmacokinetics at various dosages ranging from 100, 250, 500 and 1000 mg single doses (Kumar et al., 2016) and repeated dose studies at 500 mg/day for 30 days (Sudheeran et al., 2016).

CurQfen® is the first organic bioavailable curcumin in the market place. It contains only two GRAS-listed kitchen spices, namely curcumin from turmeric and dietary fibre from fenugreek. Organic and non-organic grades are available.

CurQfen® is available in both granular and powder formats for a variety of delivery forms. Granular is also available in non-colour leaching format employing our patented technology to prevent colour explosion in the manufacturing facility, and hence to ease the labour and to bring hygiene. Directly compressible granules with density ranging from 0.6 to 0.8 g/mL are suitable for capsules, tablets and brisk effervescence tablets, even at 600 mg/dose level and also as combinations with other botanicals. The powder is suitable for soft gels, sachets, stick packs, gummies, for liquid formulations such as liposomes, protein bars, chocolates, soups, etc.

CurQfen® production is based on our ‘Nature to Nutraceuticals®’ program by which we have adopted sustainability initiatives in terms of our own organic farms, contract farming and global sourcing for turmeric and selected farm level operations for fenugreek. Past 25 years of our journey and innovation in spices have paved the foundation and farm level knowledge on precision farming, pre & post-harvest operations, better yielded continuous extractions for supporting our customers with stable pricing and quality. We manufacture all our ingredients in-house and no trading, which makes us unique among the ingredient suppliers.

CurQfen® production is now powered by solar energy and water harvest – a 100% green process and green product to go along with the slogan GO GREEN, GO NATURAL!

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