Akay Natural Ingredients Private Limited Ambunad Malaidumthuruthu, Cochin, Aluva, Kerala 683561
Working hours: Monday - Saturday, 10:00-22:00

Research

CurQfen® is a “Spiceuticals – curcumin” developed by several years of our constant R&D efforts. The unique delivery mechanism of CurQfen® and its enhanced efficacy with regard to brain, heart, joints & liver health has been clinically evaluated and published in highly cited journals with high impact factor. It is the SCIENCE that distinguishes CurQfen® from the other bioavailable formulations of curcumin. Novel delivery mechanism, ability to provide bioactive free-form curcuminoids for longer duration with cellular uptake and improved blood-brain-barrier permeability are the key factors of CurQfen®. It is the one and only form of curcumin powder which has been investigated to enhanced free curcuminoids bioavailability in human subjects and the measurement of the ratio of free-form curcumin to the biologically inactive curcumin glucoronides.

The unique delivery mechanism of CurQfen® and its enhanced efficacy with regard to brain, heart, joints & liver health has been clinically evaluated and published in highly cited journals with high impact factor. It is the SCIENCE that distinguishes CurQfen® from the other bioavailable formulations of curcumin. Novel delivery mechanism, ability to provide bioactive free-form curcuminoids for longer duration with cellular uptake and improved blood-brain-barrier permeability are the key factors of CurQfen®. It is the one and only form of curcumin powder which has been investigated to enhanced free curcuminoids bioavailability in human subjects and the measurement of the ratio of free-form curcumin to the biologically inactive curcumin glucoronides.

Safety assessment of a highly bioavailable curcumin-galactomannoside complex (CurQfen) in healthy volunteers, with a special reference to the recent hepatotoxic reports of curcumin supplements: A 90-days prospective study

Journal of Toxicology, 2021 

Study period – 90 days
No of subjects – 34
Dosage – 1000mg/day

Result – CurQfen® was found to be safe curcumin supplement for regular consumption and is devoid of any adulterants and contaminants.

Enhanced bioavailability and relative distribution of free (unconjugated) curcuminoids following the oral administration of a food-grade formulation with fenugreek dietary fibre: A randomised double-blind crossover study

Journal of functional foods 22 ( 2016 ) 578–587

No of subjects – 50

Dosage – 250-1000mg

Result – CGM administration provided over 45.5-fold enhancement in free curcuminoids bioavailability with improved pharmacokinetics.

Improved blood–brain-barrier permeability and tissue distribution following the oral administration of a food-grade formulation of curcumin with fenugreek fibre

Journal of functional foods 14 ( 2 0 1 5 ) 215–225

No of subjects – 54 male wistar rats

Dosage – 200mg

Result – Post administration tissue samples of Wistar rats demonstrated significant enhancement in plasma bioavailability in vivo stability and blood–brainbarrier permeability as evidenced from the tissue distribution of free curcuminoids.

Brain regional pharmacokinetics following the oral administration of curcumagalactomannosides and its relation to cognitive function

Journal of Nutritional Neuroscience, 2021

No of subjects – 48 male wistar rats

Dosage – 100mg

Result – CurQfen® was able to distribute significant amount of free curcuminoids, in brain especially in the hippocampus. Administration of CurQfen® also shown positive impact in behavior of animals.

Safety, Tolerance, and Enhanced Efficacy of a Bioavailable Formulation of Curcumin With Fenugreek Dietary Fiber on Occupational Stress

Journal of Clinical Psychopharmacology, 2016

Dosage – 1000mg

Result – A significant reduction in stress, anxiety and fatigue leading to a better quality of life was observed for CurQfen® administered participants

The effects of oral administration of curcumin–galactomannan complex on brain waves are consistent with brain penetration: a randomized, double-blinded, placebo-controlled pilot study

Journal of Nutritional Neuroscience, 2020

No of subjects – 18

Dosage – 500mg

Result – Supplementation of CGM resulted in a significant increase in α- andβ-waves, a significant reduction in α/β ratio in comparison with unformulated curcumin and significant reduction in the audio-reaction time.

Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate/Glucosamine: Double-Blinded, Randomized Controlled Study

Journal of Alternative and complementary medicine, 2020; 1-11

No of subjects – 80

Dosage – 400mg x2/day

Result – Curcumagalactomannoside/Glucosamine was found to offer significant beneficial effects to pain, stiffness, and physical function of OA subjects compared with CHN-GLN, which was evident from the improvement in walking performance, VAS score, KPS score, and WOMAC score.

Influence of a low-dose supplementation of curcumagalactomannoside complex (CurQfen) in knee osteoarthritis: A randomized, open-labeled, active-controlled clinical trial

Journal of Phytotherapy Research, 2020; 1-13

No of subjects – 72

Dosage – 400mg/ day

Result – CGM exhibited 47.02, 21.43, and 206% improvement in VAS, KPS, and walking performance, respectively, compared to the baseline.

Amelioration of Radiation-Induced Damages in Mice by Curcuminoids: The Role of Bioavailability

Journal of Nutrition and cancer, 2020

No of subjects – 48 male swiss albino mice/ 24 male swiss albino mice

Dosage – 100mg

Result – Oral administration of CurQfen® was found to provide better clastogenic and genotoxic potential

Ameliorating demyelination effect of curqfen® in cuprizone induced mice model of multiple sclerosis

International Journal of Pharmacy and Pharmacology, 2019

No of subjects

Dosage – 200mg / 400mg

Result – CurQfen® at dosage of 400mg exhibited significant neuroprotection and remyelination.

Bioavailable Curcumin Alleviates Lipopolysaccharide-Induced Neuroinflammation and Improves Cognition in Experimental Animals

Journal of Pharmacognosy and Natural Products, 2019

No of subjects

Dosage – 200mg

Result – CurQfen® possesses significant enhanced cognitive effects than unformulated curcumin (IEAC No: DPS/12/2015)

Influence of enhanced bioavailable curcumin on obesity-associated cardiovascular disease risk factors and arterial function: A doubleblinded, randomized, controlled trial

Journal of Nutrition, 2019

No of subjects – 22 Men

Dosage – 500mg/day

Result  – CurQfen® improves homocysteine and high-density lipoprotein concentrations, which may promote favorable cardiovascular health.

Curcumin‐galactomannosides mitigate alcohol‐induced liver damage by inhibiting oxidative stress, hepatic inflammation, and enhance bioavailability on TLR4/MMP events compared to curcumin

Journal of Biochemical and Molecular Toxicology, 2019

No of subjects – 32 male wistar rats

Dosage – 250mg

Result – Supplementation of CurQfen®reversed all of the pathological effects of alcohol administration, almost close to the normal level, when compared with unformaulated curcumin.

Comparitive neuroprotective effects of native curcumin and its galactomannoside formulation in carbofuran induced neurotoxicity model

Natural Product Research, 2018

No of subjects

Dosage – 250mg

Result – CurQfen® was more effective in mitigating carbofuran toxicity with results comparable  to that of normal curcumin.

Curcumin–galactomannoside complex inhibits pathogenesis in Ox‑LDL‑challenged human peripheral blood mononuclear cells

Journal of Inflammopharmacology, 2018

No of subjects

Dosage

Result – CurQfen® has significant anti-inflammatory effect on ox-LDL induced inflammatory condition.

A Novel Curcumin-Galactomannoside Complex Delivery System Improves Hepatic Function Markers in Chronic Alcoholics: A Double-Blinded, randomized, Placebo-Controlled Study

Journal of BioMed Research International, 2018

No of subjects – 48

Dosage – 500mg

Result – CurQfen® was found to offer significant hepatoprotective effect towards the alcohol induced alterations to hepatic function markers.

Responsiveness to curcumin intervention is associated with reduced aortic stiffness in young, obese men with higher initial stiffness

Journal of functional foods, 2017

No of subjects – 22

Dosage – 500mg

Result – CurQfen® was found to have the potential to de-stiffen arteries in young, obese men with greater aortic stiffness

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