CurQfen delivers >70% of the absorbed curcuminoids in the bioactive FREE form
(A) Plasma concentrations of free curcuminoids by time plot following the oral administration of single dose of 1000 mg CGM containing 391 mg of total curcuminoids. Plasma concentrations were calculated with and without enzymatic hydrolysis with β-glucuronidase enzyme. Data expressed as mean ± SEM, where p < 0.05, when the plasma free curcuminoids concentrations with and without enzymatic hydrolysis was compared. (B) The relative distribution of free curcuminoids and conjugated metabolites at different post-administration time interval (Kumar et al., 2016).
Improved BBB-permeability and Brain pharmacokinetics of CurQfen: The litmus test for Brain bioavailability
CurQfen® has shown to deposit free curcuminoids, (including curcumin, DMC & BDMC) at >100 ng/g in brain tissues, with extended elimination half-life of 4 hours. Standard unformulated curcumin, on the other hand, detected only 1.4 ± 0.8 ng/g of curcumin in the brain tissues, indicating the improved BBB permeability.
Brain concentration – time curve of total free curcuminoids and individual curcuminoids (curcumin, DMC and BDMC) of Wistar rats orally administered with standard curcumin or CurQfen. The values are presented as mean ± SD (Krishnakumar et al., 2015).
CurQfen® delivers free curcuminoids in the Hippocampus. The first line of molecular evidence for its Cognitive support
Most recently published clinical trial on Nutritional Neuroscience, 2021 revealed the brain regional pharmacokinetics following the oral consumption of CurQfen® and its effect on cognitive health.
Relative distribution of curcumin among various regions of brain at 2 h post-administration time point of single (100mg/kg b.wt) and repeated dose (100 mg/kg b.wt. for 28 days). The values are given as mean ± SD (n = 3), where ‘b’ – p < 0.01
CurQfen® Improves Memory and Learning in healthy rats – Behavior studies
The effect of brain delivery of curcuminoids was also studied on behavioural changes with a set of behavioural studies on vehicle control. In RAM test, CurQfen® treated animals had shown significant reduction in working memory error and reference memory error as compared to unformulated curcumin treated animals, which clearly shows the improvement on cognitive function upon CurQfen® administration.
CurQfen® positively affects the Brain waves: The first line imaging evidence for BBB-permeability in human beings
CurQfen® was also investigated by Electroencephalography imaging (EEG) and showed for the first time that CurQfen®-curcumin can modulate brain waves in human volunteers as a proof of its BBB-permeability and brain penetration as compared to Unformulated curcumin which failed to make significant changes as observed with placebo (Nutritional Neuroscience, 2020).