Akay Natural Ingredients Private Limited Ambunad Malaidumthuruthu, Cochin, Aluva, Kerala 683561
Working hours: Monday - Saturday, 10:00-22:00

FAQ

CurQfen® is the first organic bioavailable curcumin in the market place.  It contains only two GRAS-listed kitchen spices, namely curcumin from turmeric and dietary fibre from fenugreek manufactured using our water-based process of FENUMATTM. Both Organic and Non-organic grades are available.

CurQfen® is absolutely safe. It has acute, repeated dose (28-days), subchronic (90 days) toxicity studies and genotoxicity studies (Food & Function, 2015).   It has been extensively investigated for human safety, especially with respect to liver toxicity in the light of some recent supports on hepatotoxicity issues with respect to some other curcumin supplements (Unpublished). No safety issues has been reported on CurQfen® and is Self-affirmed GRAS.

CurQfen® contains not less than 35% of curcuminoids, as the sum of curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), which means that each lot will have not less than 28% curcumin, 6.13% DMC and 0.88 % BDMC.  500 mg of a single 0 size capsule will have approximately 140mg Curcumin, 30.65mg DMC and 4.4mg BDMC with a total curcuminoids content of 175 mg.

CurQfen® is the one and only formulation which is 100% natural.  It is free from any synthetic emulsifiers such as polysorbate (Tween 80), glycerine, silica, microcrystalline cellulose, maltodextrin, polyvinyl alcohol, magnesium stearate, saturated fatty acids like palmitic acid etc..

 

CurQfen® is manufactured by a water-process employing standard unformulated curcumin and fenugreek dietary fibre. The fibre is produced by a proprietary process without using any solvents.  So, the only solvents in CurQfen® are the ones used for its isolation from turmeric rhizomes.  Either acetone, ethanol or ethyl acetate can be used as desired by the customer. No hexane or chlorinated solvents would be involved in the process.

 

CurQfen® is manufactured in a GMP certified plant with ISO 9001, ISO 14001, BS OHSAS 18001 & FSSC 22000.  It is 100% vegan, non-GMO, gluten-free, halal & kosher certified. And it also hold self-affirmed GRAS and USA patent. CurQfen® is a CLEAN-LABEL and ORGANIC ingredient.

 

And what about its solubility? CurQfen® is food-grade and suitable for powder beverages (sachets, stick packs, Golden milk), protein bars, protein supplements, gummies, yogurt, instant soup powders, chocolates, etc at 100 to 200 mg/serving size without taste issues. CurQfen® is the only bioavailable formulation of CurQfen® that has been used as a functional food ingredient and the bioavailability from the food matrix has been confirmed on humans at 100 mg dosage/serving size (Food & Function, 2014). It is water dispersible and can dissolve completely on stirring. However, a significant settling may observe on standing the water solution. But, it is good for liquid shots and liposomes.

 

Each lot of CurQfen® is analyzed for synthetic curcumin and excipients free certification by 14C-radio isotope analysis, PAH, PA, pesticides as per EPA & USP, illegal dyes, antibiotics, residual solvents, chromates, glyophosphates, heavy metals, oxalates, mycotoxins and Microbial status

 

CurQfen® does not contain any phytochemicals in fenugreek since purified dietary fibre is used for the formulation.  It is de-bitterised making it suitable for food applications.

 

 

The current practice of expressing curcumin bioavailability in the market place is ‘the measurement of plasma concentration of curcumin glucuronides/sufates’ by hydrolysis with β-glucuronidase enzyme and expressing it as ‘curcumin’ bioavailability as the NUMBER OF FOLDS of enhancement.  So, the declared bioavailability is that of curcumin-glucuronides/sulfates only; NOT the ‘curcumin’ bioavailability.  In the light of the recent studies that curcumin glucuronides have no anti-inflammatory & antiproliferative and anti-amyloidic activities, there exist a great need for a new generation of bioavailable curcumins’ capable of delivering FREE curcuminoids.

CurQfen® is a new generation bioavailable curcumin in this respect.  It is the only bioavailable curcumin in the market place whose FREE curcuminoids bioavailability has been confirmed and quantified by Triple quadruple, time-of-flight (TOF), and ion Trap tandem mass spectrometric analysis.  CurQfen® is the only formulation which has been shown the relative distribution of free curcuminoids in plasma over the conjugated curcuminoids (FCR).  That is, how much curcuminoids in plasma is in free form and how much as glucuronides. So, CurQfen® is talking about the latest understanding on curcumin absorption, beyond the “number of folds”.

Moreover, BBB-permeability, brain-regional distribution pharmacokinetics, organ tissue distribution (cellular uptake), and clinical studies on brain, heart, liver and joint-health at relatively low dosage of 500 mg/day. CurQfen has confirmed the BBB-permeability in humans using study on BRAIN WAVES. It is also 100% Natural & CLEAN LABEL & ORGANIC with no synthetic excipients, which makes CurQfen® unique and novel.

 

As per the clinical study on 50 subjects, CurQfen® has 45-fold free curcuminoids bioavailability as compared to the total absorption of 1000 mg single dose of unformulated curcuminoids 95%, when performed a triple quadruple-electrospray ionisation tandem mass spectrometric study (Kumar et al., 2016).  When compare the bioavailability of total curcuminoids as the sum of free and conjugated curcuminoids with respect to the respective curcuminoids upon a single dose of 1000 mg unformulated curcuminoids 95%, it is 270-fold bioavailable.

 

 

Three levels of mass spectrometric evaluations using Triple quadruple, Time of flight and Ion trap tandem mass spectrometry were used to confirm the curcuminoids and their metabolites.

 

 

The identification of unique physicochemical properties of fenugreek galactomannans and the invention of a proprietary water-based mechanical process for the isolation of a unique composition of phytochemicals free and debitterised dietary fibre were the key.  It binds with curcuminoids in high affinity and forms amorphous curcumagalactomannosides (curcumin-galactomannan biocomplex or CGM) exhibiting mucoadhesive character. CGM swells extensively in the gastrointestinal tract, binds with the epithelial membranes and leaches the colloidal nano sized soluble curcuminoids (sustained release) from the galactomannan network and absorbs via both circulatory and lymphatic systems. It is a ‘Self-emulsifying hydrogel-mediated delivery system’ using natural polymer (biopolymer).

 

 

 

CurQfen® is available in both granular and powder formats for a variety of delivery forms.  Granular is also available in non-colour leaching format employing our patented technology to prevent colour explosion in the manufacturing facility, and hence to ease the labour and to bring hygiene.  Directly compressible granules with density ranging from 0.6 to 0.8 g/mL are suitable for capsules, tablets and brisk effervescence tablets, even at 600 mg/dose level and also as combinations with other botanicals. Powder is suitable for soft gels, sachets, stick packs, gummies, for liquid formulations such as liposomes, protein bars, chocolates, soups, etc.

We offer various grades, CurQfen NQ, CurQfen FQ and CurQfen BQ for various kinds of food applications and pharmadelivery forms. Contact us for more details.

 

 

CurQfen® production is based on our ‘Nature to Nutraceuticals®’ program by which we have adopted sustainability initiatives in terms of our own organic farms, contract farming and global sourcing for turmeric and selected farm level operations for fenugreek.  Past 25 years of our journey and innovation in spices have paved the foundation and farm level knowledge on precision farming, pre & post-harvest operations, better yielded continuous extractions for supporting our customers with stable pricing and quality.  We manufacture all our ingredients in-house and no trading, which makes us unique among the ingredient suppliers.

 

 

 

 

 

 

 

 

CurQfen® production is now powered by solar energy and water harvest – a 100% green process and green product to go along with the slogan GO GREEN, GO NATURAL !

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